- Structural Biology - RSC Advances (RSC Publishing)
- Advances in Protein Chemistry and Structural Biology, Vol 80
- Citations per year
- Advances in Protein Chemistry and Structural Biology, Volume 84
- Advances in Protein Chemistry and Structural Biology, Volume 80.
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For example, in , Chinese research groups at Tsinghua University and the National Laboratory of Biomacromolecules Institute of Biophysics, Chinese Academy of Sciences , determined the crystal structure of the mitochondrial respiratory membrane protein complex II , also known as mitochondrial succinate:ubiquinone oxidoreductase, a tour de force in biomolecular crystallography. This macromolecular machine couples the Krebs cycle with the electron transport chain, producing most of the energy in eukaryotic cells. The structure was a marked breakthrough not only in crystallographic studies of membrane proteins, but also in the field of bioenergetics.
Structural Biology - RSC Advances (RSC Publishing)
Over the last decade or so, there have been many important structures coming out of Asia including influenza A virus, a plant light-harvesting complex, cytochrome c oxidase, bacteriorhodopsin, nicotinic acetylcholine receptor, aquaporin 1, a voltage-sensitive sodium channel and a glutamate transporter, to highlight a few.
Asian countries — including Japan, China, India and Korea — have also supported efforts in the worldwide structural genomics initiative — aimed at the large scale mapping of protein structure space by determining all the protein structures within selected genomes. Japan particularly has been a global leader in this area, initiating projects such as the RIKEN Structural Genomics Initiative as early as to determine bacterial, mammalian and plant protein structures.
Such projects also provide unprecedented opportunities for structure-based drug design and medicinal chemistry using high-throughput crystallography. Increasingly, industry-university-government collaborations in Asia are being explored for drug discovery innovation. Takeda, a large pharmaceutical company in Japan, has undertaken such open innovation collaborations. Not all major discoveries need expensive equipment and huge teams of people, but rather just clear thought and vision.
Advances in Protein Chemistry and Structural Biology, Vol 80
An example of a long-standing contribution to crystallography that highlights this is from G. He was able to show that indeed there are limits imposed on polypeptide chain conformation by the need for non-bonded atoms to avoid bumping against each other. This was the genesis in of the Ramachandran plot of allowed peptide backbone geometries, which is still used today as the criteria to validate every protein structure. Zhou, Z. Liu, H. Nibert eds, Horizon Scientific Press , Liu, F.
Citations per year
Wan, Y. Kong, Y. Biol , , 1 , Bortz, E. Whitelegge, J. Jia, Q.
Stewart, J. Wu, T. Sun, R. In: Thiamine, Jordan F. Eds , , Xia, Q. Chem , , , Lo, P. Virol , , 77, Dai, W Liang, Y Zhou, ZH, Web portal to an image database for high-resolution three-dimensional reconstruction, Journal of structural biology , , , Chiu, W. Published continuously since , the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists.
Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. The intended audiences for this volume are researchers and specialists in protein structure and interactions, cancer biology, psychiatry and mass spectrometry.
This volume would be also of a great use to students working on projects from the abovementioned areas. In Dr.
Advances in Protein Chemistry and Structural Biology, Volume 84
Donev was appointed Senior Lecturer at Swansea University. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks.
Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment.
More recently he has focused on design of antibody-based oral treatment of pathological conditions of the gastrointestinal tract. We are always looking for ways to improve customer experience on Elsevier. We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit. If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website.